what are the critical parameter adjustments

[Ehallman]

I was trying to methodically change settings to optimize my latency and jitter but the variability muddies everything.  Can someone tell me what variables are the most critical for reducing latency and jitter.  I'm on a Mac so looking at the Audio Booster settings, I assume Frame Size is most important but after that which of the following should be tweaked next:
   Outgoing Audio Bitrate
   Network Packet Rate
Should the Auto Throttles be on?
Is there a trade off on optimizing latency versus jitter?

Thanks,