constant resync

[sctthffrbr@gmail.com]

I am in Atlanta the other musicians I was playing with last night are in New York and Minnesota.   i have a solid internet connection (220 - 250 Mbps download 10 Mbps  upload)  i am using a Presonus AudioBox iTwo.   I am using one of the connections for vocals and the other for an acoustic guitar.   In the last couple of weeks,  i get cut off and get a fast clipping sound that only stops when i hit the re-sync button. Last night this was happening every 20 - 30 seconds until i gave up the session.   

I went back in on my own and set a solo session and didnt have any of the interference.  For argument's sake i recorded the couple of songs that i did in this session , just so that i could prove i was going through the application   

Any assistance would be appreciated 

But - no one directly addressed the question - What  causes "constant resync"? Are you saying this is strictly a speed issue? A latency issue? WHAT??